Assessing liver stiffness with conventional cut‐off values overestimates liver fibrosis staging in patients who received the Fontan procedure

Aim Patients who undergo the Fontan procedure for complex congenital heart disease are prone to liver cirrhosis. Liver stiffness (LS) reflects fibrosis stage in patients with chronic viral hepatitis; however, its accuracy predicting is controversial. We aimed clarify correlation between LS and patients. Methods Fifty-eight were prospectively measured transient elastography. undertook biopsy, cardiac catheterization, laboratory tests 22 of these (median age, 14.7 years; range, 9.9–32.1 years) > 11.0 kPa (median, 19.2 kPa; 12.2–39.8 kPa); elevated values suggest Results Histologically, all showed mild-to-severe portal sinusoidal but no Statistically, did not predict histological scores (p = 0.175). was correlated central venous pressure 0.456) or hepatic gradient (HVPG; p 0.062), although value HVPG only slightly above threshold significance. Conclusions developing both fibrosis. could be influenced by HVPG, using conventional cut-off overestimates overtreats